MATRIXYL
Cosmetic interest (properties):
MATRIXYL constitutes a revolutionary ingredient to treating wrinkles and a remarkable alternative to retinol and vitamin C. Repairing the matrix and the epidermal-dermal junction constitutes the mechanism of wrinkle reduction. MATRIXYL also stimulates wound healing gene expression.
Applications:
Products for wrinkle prevention and repair, eye contour care, mature skin range of products.
IN VITRO
Summary of the results obtained by KATAYAMA (1993) on peptide Lys-Thr-Thr-Lys-Ser (KTTKS):
-Stimulation of collagen I and III, and fibronectin synthesis : + 320% with 50 mM

Neosynthesis (in these tests, Matrixyl was compared to vitamin C and TGFb):
-Stimulation of collagen IV synthesis on aged fibroblasts : + 257% with 4% MATRIXYL
-Stimulation of glycosaminoglycan synthesis on fibroblasts : + 267% with 2% MATRIXYL

Molecular biology – Study of gene activation in fibroblasts and in 3D epidermis.

Results: Stimulation of 16 genes specific of skin healing.
Neosynthesis of collagen on human skin biopsies: 

-Stimulation of collagen synthesis:

MATRIXYL 2% (2ppm pal-KTTKS) +30%

MATRIXYL 4% (4ppm pal-KTTKS) +117%
IN VIVO
Profilometry and image analysis – 6-month study:
Against placebo:
25 volunteers / Twice-daily application on half face of a cream containing 3% 
MATRIXYL versus placebo
Image analysis by profilometry
 
-Wrinkle depth : -21.6%*
-Roughness : -16.4%*
-Wrinkle volume : -24.4%*
-Main lines density : -46.8%*
-Wrinkles surface : -67.8%*

Significant with regard to l0 (p<0.01)
Against vitamin C:
10 volunteers / Twice-daily application on half face of a cream containing 3% 
MATRIXYL versus a commercially available cream containing 5% vitamin C / 
Image analysis by profilometry
 
Matrixyl Vit. C
-Wrinkle depth -21.8%* 1.1%ns
-Roughness -13.5%** 3.6%ns
-Wrinkle volume -24.4%* 0.3%ns
-Main lines density -32.8%** 17.8%ns
-Wrinkles surface -49.3%** 28.0%ns

*significant with regard to vitamin C (p<0.07)
**highly significant with regard to vitamin c (p<0.01)
ns no significant

Matrixyl confirms its strong anti-wrinkle efficacy whereas the cream with vitamin C is inactive Profilometry and image analysis – 2 and 4-month study versus RETINOL:
16 volunteers / daily application for two months then twice-daily application for the two following months / cream containing 3% MATRIXYL versus cream containing 0.07% Retinol / Image analysis by profilometry, dermatological evaluation and echography.
Profilometry and image analysis – 2 and 4-month study versus RETINOL:
16 volunteers / daily application for two months then twice-daily application for the two following months / cream containing 3% MATRIXYL versus cream containing 0.07% Retinol / Image analysis by profilometry, \dermatological evaluation and echography.
 
Dermatological evaluation
MATRIXYL 4%
Retinol
Variation with regard 
to T0 (%) 2 months 4 months 2 months 4 months
Forehead -26.67 -31.11 -20.00 -28.89
Periorbital area -13.46 -19.23 -11.32 -16.98
Nasogenian groove -00.20 -20.41 -09.80 -25.49

The anti-wrinkle efficacy of MATRIXYL is confirmed and acts more rapidly than retinol (and without irritation phenomena).

Skin thickness increases by 6.5% in 2 months and 8.6% in 4 months.

Evaluation by the Dermatologist confirms the anti-wrinkle effect, even on the forehead and the perinasal area.

In vivo study in collaboration with Professor REVUZ from Mondor Hospital
Profilometry and image analysis – 2 and 4-month study versus placebo

Two groups of 30 volunteers / Twice-daily application on face and décolleté for 4 months of a cream containing 5% MATRIXYL for one group and a placebo for the other / Image analysis by profilometry on Silflo prints at T0, T2 and T4 months. Biopsies on 12 volunteers.
MATRIXYL, which peptide belongs to the family of Matrikines (Peptidic fragments, messengers or the natural process of tissue repair), is designed to replace retinol and its esters as an efficient anti-wrinkle active ingredient. It acts through specific mechanisms, without any toxicological danger.

MATRIXYL equals and exceeds retinol activity. It can be incorporated in any skin care product all over the world.
 
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